For topical treatment of respiratory diseases complex of essential oils, namely ginger (Olei Zingiber officinale), clary (Olei Salvia sclarea), marjoram (Olei Majarana hortensis) and tea tree (Olei Melaleuca alternifolia) were selected as active substances [1, 2]. Choice of gelling agent and rational technology of introduction of active substances and excipients was justified. It was studied the impact of the solution with complex of essential oils on the structural and mechanical (structural viscosity, shear stress, the type of flow), physical and chemical (colloidal stability, pH) properties of the gel system in order to justify the selection of optimal gelling agent, as to ensure the stability of the drug within 24 months. The study of structural and mechanical properties of the developed samples was performed on a rotary viscometer Brookfield DV-II + PRO (USA), spindle SC4-21. According to the results of the study the optimal gelling agent, which ensures the creation of a stable gel base with essential oils complex, was selected [3].