The objective of the work was to isolate active phytoconstituents present in the herb Coldenia procumbens. Phytochemical investigation of the aerial parts of the plant yielded rare Nitrile glucosides, Ehretioside A1 1 and Lithospermoside (Griflonin) 2. The structures of the compounds were established on the basis of various NMR and Mass spectral data. The cyano-containing compounds 1 and 2 were isolated for the first time from C. procumbens.