Different medications used in successful quitting of smoking are discussed is present article. An attempt was made to develop and validate a novel, simple, cost effective, accurate, and reproducible analytical methods to Varenicline (VRC), Bupropion, nortriptyline and clonidine in bulk and pharmaceutical formulations. Varenicline is a highly selective partial agonist of the nicotinic acetylcholine receptor α4β2 subtype. Varenicline works by preventing nicotine from reaching nicotine receptors in the brain and by stimulating dopamine production both of which make cigarettes less satisfying. Varenicline trials concluded that the drug doubled the chances of successfully quitting compared to unassisted quitting. Bupropion is a second-generation antidepressant agent that is also used in the management of smoking cessation. Analysis of pharmaceutical products covers every aspects of quality control of active pharmaceutical ingredients (API) and finished products. This method was validated according to ICH guidelines. Validated method has proved to be linear, accurate, precise, and robust, it is suitable for pharmacokinetic assays, such as bioavailability and bioequivalence, and is being successfully applied as antismoking agent.