A simple, accurate and precise validated RP-HPLC method for determination of Galantamine Hydrobromide has been developed. Analysis was carried out on Shimadzu HPLC system with Phenomenex C18 column (250 x 4.6 mm i.d, 5µm particle size) using 1 mM ammonium formate: acetonitrile (30:70) in Isocratic mode as mobile phase with flow rate of 0.4 ml.min-1. The detection was carried out using UV detector set at 289 nm. For this method, Beer’s law is obeyed in the concentration range of 100 to 1000 µg mL–1 of Galantamin Hydrobromide. The developed method has been successfully applied for the analysis of drug in bulk and pharmaceutical formulations. The mean percent recoveries were found to be 99.8 ± 0.13 for Brand formulation. The method was validated with respect to linearity, precision and accuracy as per the International Conference on Harmonisation (ICH) guidelines.