Quality of anti-malarial drugs in malaria endemic countries needs more attention than ever before due to increased circulation of substandard drugs in the society. In this study, physicochemical quality parameter test of common brands of chloroquine tablet dosage forms obtained from Northern part of Nigeria was evaluated using appropriate methods. The level of non-compliance with respect to registration with NAFDAC and manufacturer’s address, weight variation, friability, hardness and disintegration are 12.5%, 12.5%, 71.43%, 28.57% and 0% respectively. The results indicated gross quality failure of all the quality parameters analyzed, therefore there is urgent need to prompt for action in order to arrest the situation, otherwise the region and the country as whole is at risk. This study serves as a litmus test for drug quality condition for the entire country.