The anticonvulsant activity of 6-aryl- 6H- pyrrolo (3, 4-d) pyridazine (PPZ) analogues was quantitatively analyzed in terms of physico chemica l parameters by regression analysis. Structural requirements for maximal binding affinit y to a novel site of α 2 δ subunit were derived. The leave –one –out cross validation method was use d to judge the predictive power of model equations. The high binding affinity of molecule is expected to have more bulky and electron donating groups.