Pyridazinone derivatives constitute an important class of heterocyclic in drug discovery. The interesting groups of this compound have diverse biological activities such as antibacterial, antifungal, anti-inflammatory, anticancer, anti-tubercular, antihypertensive and analgesic activities. Interestingly, It also shows insecticide and herbicide activity. In the present review, our main interest is to emphasize the various synthetic molecules of pyridazinone analogs along with their pharmacological significance which is also presented.