Charge transfer complexes based on tyramine (Ty) (4-(2-aminoethyl) phenol) organic basic donor and π -acceptors having acidic protons such as picric acid (PA), and chloroanilic acid (CA) with the compositions, [(Ty)(CA)2] and [(Ty)(PA)2] have been synthesized and the chemical structures were confirmed by thermal analysis and physicochemical studies such as UV visible, FT-IR and 1H-NMR spectral studies. Spectroscopy measurements show that the donor–acceptor molar ratio was found to be 1: 2 for both (Ty): (PA) and (Ty): (CA) charge transfer complexes, in addition to that the ArNH+ 3 ammonium ion and OH2+ were formed under the acid–base theory through proton transfer from an acidic to basic centers in charge transfer complexes, as well as the spectroscopic data were discussed in terms of formation constant (KCT) and molar extinction coefficient (eCT). Thermal behavior of both charge transfer complexes showed that the complexes were more stable than their parents.