The major aim of the present study is to focus the anti-inflammatory and anti-angiogenic potential of Emodin in 7, 12-dimethylbenz[a]anthracene (DMBA) induced oral carcinogenesis in the golden Syrian hamsters. Oral squamous cell carcinoma was induced in the buccal pouches of hamsters using the organ and site specific carcinogen, DMBA. Tumor incidence in DMBA alone and DMBA + Emodin treated hamsters was found to be 100% and 0% respectively. A mild to moderate preneoplastic lesions was, however, observed in the buccal mucosa of DMBA + Emodin treated hamsters. Emodin suppressed the formation of tumors by down-regulating the expression of inflammatory (NFκB, COX-2, iNOS, IL-6 and IL-10) and angiogenic (VEGF) markers in DMBA treated hamsters. To conclude, Emodin has exerted a potent anti-inflammatory and anti-angiogenic properties during DMBA induced oral carcinogenesis.