Protective effect of an aqueous leaf extract of Solanum nigrum and Solanum trilobatum extract was examined against lead acetate Swiss albino mice. The oral administration of the above extract for 30 days against lead acetate affected mice significantly increased the levels of antioxidants (SOD,CAT, GPx) and decreased the level of lipid peroxidation (LPO).The results of the present study, for the first time, provide clear evidence of defence provided by S.nigrum and S.trilobatum extracts against lead acetate induced toxicity in brains of albino mice.