The present article is to find out the prescription trends in Mamata Medial College, Khammam in Department of Orthopedics. Prescriptions from both OPD as well as IPD were collected and analyzed with the following parameters: Average number of drugs per prescription, Percentage of drugs prescribed by generic name, Dosage frequency and Duration of treatment, Disease distribution, percentage of drugs prescribed from essential drugs list or formulary. Number of drugs per prescription varied from 1 to 6 with average of 2.133. Dosage forms were recorded in 95% of prescriptions. The frequency of drug administration was recorded in 100% prescriptions whereas only 82% of prescriptions mentioned regarding duration of the treatment. Antimicrobials (15.64 %) and NSAIDs (40.13%) constituted the most routinely prescribed drugs among all the classes. Also most of the antimicrobials have been prescribed parent rely (95%). Suggestions were given to the doctors to prescribe drugs among the hospital formulary to reduce the economic burden to the patients since percentage of drugs prescribed among hospital formulary was only 79.93%.