The present study includes preparation and optimization of Rosiglitazone maleate bi layered floating - bio adhesive tablets. The first layer is a fast releasing layer consisting of a loading dose of the drug prepared by wet granulation method while the second layer is a sustaining layer containing maintenance dose of the drug.The loading dose was directly compressed onto the sustaining layer. The scope of the present work focuses on the development of matrix floating tablet by incorporating a high dose of freely soluble active substance with high viscosity polymers achieving a sustained release for 24 hrs to target the stomach. Different grades of Hydroxypropylmethylcellulose K4M, hydroxypropylmethylcellulose K10M and Sodium carboxy methyl cellulose were used as swell able polymers. Drug-polymer compatibility was assessed by FTIR studies. The granules and tablets were subjected to evaluation of various pre compression and post compression parameters. Results were found to be within the acceptable limits. The results of in vitro release data indicate that for all formulations, drug release is through diffusion pathway and the mechanism of Rosiglitazone maleate release from the floating layer followed first order case II transport. Based on the results of t50, optimized formulation was F5. Desired gastric retention and controlled drug delivery is achieved.