The present study aims to prepare ternary blend films composed of chitosan/guar gum/vanillin (CH/GG/Vn) by solvent casting method. The surface morphology and interaction among the components of blend films were determined by Atomic force microscopy (AFM) and Fourier transform infrared spectroscopy (FTIR). The blend films were subjected to swelling study under water and different pH media. The roughness of the blend films increased with increase in guar gum and vanillin (wt%). By the addition of equal weight percent of GG/Vn into chitosan film, the swelling behavior enhanced than pure chitosan and swelling behavior at different pH medium than water. Based on the results, we conclude that the prepared blend films can find potential application in pharmaceutical industry for drug delivery.