The present study objective was to develop novel co lon specific drug delivery systems for aceclofenac using pectin as a microbially degradabl e polymeric carrier and to coat the optimized batches with a pH dependent polymeric coating solut ion containing Eudragit L 100 and S 100 (1:4). Pellets containing four proportions of pecti n were prepared. The pellets were evaluated for physicochemical properties, drug content, dissoluti on, water uptake & erosion characteristics, in vitro drug release studies. The amount of aceclofen ac released from the pectin pellets at different time intervals was estimated by UV spectrophotometr ic method at 275nm. Eudragit coated pectin pellets prevented release of the aceclofenac in the physiological environment of stomach and small intestine depending on the proportion of pectin used in the formulation. The dissolution profile and in vitro release kinetics showed that pectin pellets were p romising for controlled delivery of the drug. The findings of th e present study conclusively state that pectin pellets are promising for colon targeting of aceclo fenac to synchronize the chronobiological symptoms for effective treatment of rheumatoid arth ritis.