A valuable Indian ethnomedicinal plant, Drypetes sepiaria (Wight & Arn.) Pax. & Hoffim was investigated to determine the phytochemical constituents present in various extracts of the leaves through GC-MS (Gas Chromatography-Mass Spectrometry) analysis. Powdered leaf plant materials were subjected to successive extraction with organic solvents such as methanol by Soxhlet extraction method. In the present study, a total of 23 different compounds identified by GC-MS analysis using methanol extract, all the identified compounds were medicinally valuable for the treatment of various human ailments. In addition, all the phytochemical compounds were needed for further investigations on toxicological aspects for the development of new lead of therapeutic interest.