Over the past few years natural products have become increasingly popular and the field of natural herbal remedies has flourished to a great extent. Natural herbs have been used for Medicinal purposes for many countries, and continue to be a medicament for various ailments even with the revolution in antibiotics and other synthetic medicine in modern scientific world. Pyrexia or fever is caused as a secondary impact of infection, malignancy or other diseased states. It is the body’s natural function to create an environment where infectious agents or damaged tissues cannot survive. It is now clear that most antipyretics work by inhibiting the enzyme cyclooxygenase and reducing the levels of PGE2 within the hypothalamus. Recently, other mechanisms of action for antipyretic drugs have been suggested, including their ability to reduce pro inflammatory mediators, enhance anti-inflammatory signals at sites of injury, or boost antipyretic messages within the brain. Here we summarized the plants used previously and recently identified for pre-clinical treatment of pyrexia. The present paper is a comprehensive review of different literature sources. The paper discusses the potential of different medicinal plants in curing pyrexia by animal models