Objectives: This study aimed to assess the practice of community residents in Greater Lagro, Quezon City, on antibiotics consumption. Methodology: A questionnaire-based survey was conducted on 340 residents in Greater Lagro, Quezon City, Philippines, whereby their practices regarding antibiotic use was assessed by using a five point Likert scale, whose responses ranged from “strongly agree” to “strongly disagree” and “always” to “never.” A self-made validated survey instrument was used. [Practices-self-medication: α =0.83(Good); Practices- Doctor’s prescription: α =0.682 (Acceptable)] Simple descriptive statistics was then applied, particularly the use of mean. Findings: The study showed that the respondents were uncertain that they could get trustworthy information about antibiotics from doctors and pharmacists and were also uncertain if expensive antibiotics are more effective than the cheaper ones. Alarmingly, malpractices such as non-compliance to complete antibiotic therapy for seven days, not discarding the leftover antibiotics, and giving away leftover antibiotic drugs were noted. These practices could contribute to antibiotic resistance. Conclusion: The misuse of antibiotics and the development of antibiotic resistance are fundamental public health problems, and necessary plans and actions to combat these should be taken into action immediately.