Oroxylum indicum Vent., ( Bignoniaceae ) tree roots form ingredients of Ayurvedic formulation, Dasamoola . M ethanolic extract of the root bark was tested for its in vivo antioxidant and anti inflammatory activities , followed by phytochemical analyses . Anti oxidant effect of O . indicum root bark extract was studied on sodium fluoride mediated oxidative stress - induced animals. A nimals were pre - treated orally with the extract at dosages of 200 and 400 mg/kg b.wt. Standard group received 3mM/L/day of ascorbic acid orally . From 8th day onwards, oxidative stress induction was carri ed out by the administration of 600 ppm/day of sodium fluoride orally which continued upto 14th day, along with extract treatment. A ntioxidan t profile of blood, measured as superoxide dismutase activity (SOD) and glutathione level were found to be enhanced in O. indicum extract treated group (OIM) and standard group, when compared to untreated control. Similar trend was noticed in SOD, GSH and GPx levels in liver tissue, even after sodium fluoride challenge. Extract treatment significantly reduced the extent of lipid peroxidation in liver tissue. In acute and chronic paw oedema models treated with dosages of the extract at 150 and 300 mg/kg b.wt., significant reduction in infl ammation was observed, when compared to the control animals. The extent of inhibition of oedema in carrageenan induced acute models and formalin induced chronic models were 41.28 and 48.57% respectively, for the high dosage groups. Preliminary phytochemical screening r e vealed the presence of alkaloids, flavonoids, phenols, tannins and terpenoids in the extract .