Calotropis procera R.Br., is a perennial shrub, commonly known as Aawk, milkweed or wasteland weed. It is a member of family Asclepiadaceae, leaf and stem were evaluated for its phytoconstituents, which is used in several traditional medicines to cure various diseases. This shrub has been known to possess analgesic, antitumor, antihelmintic, antioxidant, hepatoprotective, antidiarrhoeal, anticonvulsant, antimicrobial, oestrogenic, antinociceptive, and antimalarial activity. The leaves and dry stem were extracted with 70% ethanol and concentrated to obtain residue. Phytochemical screening reveals the presence of alkaloids, cardiac glycosides, flavonoids, steroids, tannins, triterpenoids, carbohydrates and saponins in the hydroalcoholic leaf extract of Calotropis procera R.Br.,