Many traditionally used plants hold importance in modern days medical regimen as they have been proved scientifically to posses various activity which are desirable, one of such plant is Vitex negundo Linn which is distributed throughout India. It is large aromatic shrub belonging to the family Verbenaceae growing in moist or along the water courses. Phytochemical investigation shows the presence of flavonoids, essential oils, flavonoid glycosides, terpenes, lignans, stilbene derivative and irridoid glycosides and possesses enormous pharmacological activities like anti-inflammatory, antioxidant, analgesic, antipyretic ,antibacterial, antitumor, anti-arthritic, anti amnesic, anxiolytic, larvicidal activity, nephroprotective activity, anti HIV activity, anti-eosinophilic and anti snake venom activity. Here in we present a review of all such data related to Vitex negundo Linn.