The present investigation was focused on the preliminary phytochemical and Fourier Transform Infrared Spectral analysis of Caralluma geniculata Grav. et Myur. The aqueous and organic solvent extracts (Petroleum ether, chloroform, ethanol and acetone) from the aerial part of Caralluma geniculata (Asclepiadaceae) were tested for the availability of flavonoids, phenolic compounds, saponins, terpenoids, steroids, proteins, coumarins, quinones and phytosterols. The FT-IR spectrum showed the presence of alkyne (C-H), methylene (C-H), isocyanate (-N=C=O), organic nitrates, aliphatic nitro compounds, ammonium ion and aromatic nitro compounds. The results confirm the fact that this plant posses’ important bioactive constituents useful for our health so further scientific investigation is needed.