Degradation of phenol by microwave irradiation was carried out to study effect of pH, initial phenol concentration and irradiation time. The effects of two different catalysts such as Titanium dioxide (TiO2) and Zinc oxide (ZnO) on phenol degradation was investigated. At pH 7, percentage phenol degradation was 37% and 27% for 50 mg/l and 75 mg/l respectively in 90s.In absence of catalyst the experimental data showed steady decreases in percentage degradation as initial phenol concentration increases from 5 mg/l to 100 mg/l. In the presence of catalyst percentage degradation increased from 19% to 44% for same concentration of phenol in 90s. The degradation follows zero order kinetics with rate constant of ko= 0.17225 s-1.