This study aimed to examine the effect of Passiflor a foetida Linnextractsat a dose of 400 mg/kgbw agai nst streptozotocin-induced diabetic mice. This research used 30 male mice which divided into three treatme nt groups. The groups arethe control group,the Streptocotozin (SZT) group, and the group of ethanol extract of th ePassiflora foetida Linn herb for dose of 400 mg/kgbw. All grou ps were induced by SZT except control group.Blood g lucose levels were measured before and after mice induced intraperitoneally with STZ dose 100 mg/kgbw. Statis tical analysis showed that the control group and STZ gr oup were significantly different (p<0.05). The SZT group showed significantly different (p<0.05) fromextract doseof 400 mg/kgbw in mice. Based on the results, this study concluded that the ethanol extract of Passiflora fo etida Linn has effect on lowering blood glucose lev els in diabetic mice