To improve the extraction rate of Acanthopanax sessiliflorus (Rupr. et Maxim.) Seem anthocyanins, the method of ultrasonic-microwave synergistic extraction (UMSE) was used. Response surface methodology (RSM) using a central composite design (CCD) was employed to optimize the conditions of ultrasonic-microwave synergistic extraction (UMSE), and the mathematical model was constructed. The results show that ultrasonic power 120W, microwave power 180W, and extraction time 6.7min, the anthocyanins extraction rate of Acanthopanax sessiliflorus (Rupr. et Maxim.) Seem is 83.42%.