Ex-vivo effects of methanol extracts of the leaves of Ocimum sanctum and fruit powder of Mallotus philippinensis were tested against phosphatases like alkaline phosphatase (ALPase), acid phosphatase (ACPase) and adenosine triphosphatase (ATPase) and glycolytic enzymes such as lactate dehydrogenase (LDH) and Malate dehydrogenase (MDH) of Moniezia expansa. Ex-vivo treatment of Moniezia expansa with plant extracts increased the activity of phosphatases whereas it decreased the activitity of glycolytic enzymes. The increased activity of phosphatases signifies damage to tissues whereas decreased activity of glycolytic enzymes may reduce the energy production of parasite. Both the extracts need further investigation for their anthelmintic activity.