A potential method for one-pot synthesis of Schiff base compounds derived from different aldehyde and Di-amine compounds like substituted aromatic aldehyde and Diamines; such as Salicylaldehyde, 3, 4-Tertery butyl 2-Hydroxy Benzaldhyde, Ethylene Diamine, 2-Amino Pyridine, 1, 2-Di-amino Benzene, 1, 3-Diamino Propane by using catalytic amount of P2O5/SiO2 have catalyzed the ligand formation in dry media under free-solvent condition at room temperature. This type of excellent method avoids use of hazardous solvents, longer reaction time and tedious work up procedure. Advantage of this efficient method is excellent yield of products in crystalline form, short reaction time, simplicity of work up procedure and no use of any type of hazardous solvents. Simply this reaction is environmentally Proctive (non polluted) and economically attractive method for synthesis of Schiff base compound. All these Schiff base compounds were characterized by means of IR, 1H-NMR and their Elemental analysis as (C, H, N, and O) spectral analysis data. Above Schiff base compounds shows inherent new generation of series of pharmaceutically important compounds.