The multi-phase multi-compartment capsule based combination pulsatile delivery system was developed which consist of four parts i.e. fast dissolving tablet of Ketorolac Tromethamine, Microspheres of Ketorolac Tromethamine, Floating tablet of Omeprazole and Plug. Fast dissolving tablets were prepared by varying proportion of disintegrant such as Sodium starch glycollate, Croscarmelose sodium, Crospovidone by Direct Compression Method. Microspheres are prepared by Solvent Diffusion Method. Floating tablet of Omeprazole was prepared by varying proportion of HPMC K4M, HPMC K15M, HPMC K 100M and Plug was prepared by using HPMC E5. The prepared formulations were evaluated for different physicochemical parameters and in vitro studies. Promising results indicated the usefulness of the Innercap technique for pulsatiledrug delivery of Ketorolac Tromethamine.