Visible spectrophotometric methods are developed for the quantitative determination of protriptyline HCl (PTP) in bulk and pharmaceutical formulations. The first method (method A) is based on the condensation of amino group of PTP with acetaldehyde to give N-alkyl vinyl amine which reacts with p- Chloranil (p-CA) to give vinyl amino substituted quinine in 1,4-dioxane. The blue colored product exhibits absorption maximum at 669 nm and linear within the limits 2.0-14.0 μg mL-1. The second method (method B) is based on the reaction of drug with 1,2- napthaquinone-4-sulphonic acid (NQS) to form N-alkylamono naphthaquinone in basic medium. The red colored product exhibits absorption maximum at 484 nm and linear within the limits 15.0-35.0 μg mL-1. The molar absorptivity and Sandell’s sensitivity of method Aand method B are 1.03 × 10 4 , 2.89 × 10-2 and 0.96 × 10 4 , 3.10 × 10-2, respectively. The statistical treatment of the experimental results indicates the precision and accuracy of the methods. Both the methods are free from interference of the ingredients such as lactose, sucrose starch, etc., thus it is successfully applied to pharmaceutical formulations. This study represents the first report on the development of new visible spectrophotometric methods for the determination of PTP.