The recent scientific and patented literature concluded that an increased interest in nanoparticle vesicular systems like liposomes, niosomes etc. has been shown in last few decades. A nanomaterial is a material with one or more external dimensions, or an internal structure, on the nano scale which could exhibit novel characteristics compared to the same material without nano scale features. Role of self assembeled structure as a vehicle is significant over the years. Their applications have been found for all routes of delivery. These micron and nano structures are containers loaded with drugs which are ideal for sustained and targeted release of the drug. Drug efficacy depends on the drug loaded into the vehicle, temperature, drug solubility, pH, release characteristics, additives and most significantly, the vehicle morphology. In this review we specially focused on nano-particles (liposomes and niosomes) which can be successfully used as a drug carrier in drug delivery systems.