Wound healing management has always been an interesting field of research till date due to serious need for new wound treatment. Appropriate wound care is a significant challenge because of the complications associated with wounds as well as low permeability through the skin. The chronic nature and associated complications of nonhealing wounds have led to the emergence of nanotechnology-based therapies that aim at facilitating the healing process and ultimately repairing the injured tissue. They offer several benefits in the healing process such as decrease in drug’s cytotoxicity, administration of poorly watersoluble drugs, better skin permeation, controlled release behavior, antimicrobial activity, as well as stimulation of fibroblast proliferation and reduced inflammation. In this outlook, present review highlights the recently developed nanotechnology-based promising strategies that can advance the wound-healing field.