The purpose of this study was to synthesize substituted 3,4-dihydropyrimidin-2(1H)-ones (DHP) and to evaluate them for their antibacterial and antifungal activities. These compounds were synthesized by cyclocondensation reaction between 3,4-dimethoxybenzaldehyde (veratraldehyde), active methylene compounds (acetyl acetone or acetoacetic ester) and urea / thiourea in presence of CuCl2.2H2O and HCl by grindstone technique. The products are obtained in good yield under mild, solvent free and ecofriendly conditions. The structures of these compounds have been confirmed on the basis of their IR and NMR spectral data. The dihydropyrimidinone derivatives synthesized have been tested for antibacterial activity against Micrococcus luteus, Escherichia coli & Pseudomonas aeruginosa and for antifungal activity against Aspergillus niger, Candida albicans & Candida kefyr.