Carbon tetra chloride a major cause of chronic liver damage represents a clinical problem. We investicated the role of Carica papaya Linn. and Solanum torvum Linn.on lysosomal activity in carbon tetrachloride vapour induced liver damage in rats. Carbon tetrachloride vapour induced liver damage and its prevention by Carica papaya Linn. and Solanum torvum Linn. were assessed on lysosomal enzyme activity and biochemical parameters like serum alanine amino transferase (SGOT), serum aspartate amino transferase (SGPT), alkaline phosphatase (APL), bilirubin and total protein. The results showed carbon tetra chloride damage associated with activities of lysosomal enzymes viz NAG, glucoronitase , acid phosphatase and also increase in serum alanine aminotransferase, serum aspartate amino transferase , alkaline phosphatase and bilirubin levels. Carica papaya Linn. and Solanum torvum Linn. reversed the effect of carbon tetrachloride vapour induced liver damage.