A series of some 5-pyridyll-2-[(N-substituted phenyl) thioacetamido]-1,3,4-oxadiazoles were synthesized by both conventional and microwave method and characterized on the basis of IR, NMR Mass Spectral and elemental analysis. The title compounds were subjected for antibacterial activity against both gram positive and gram negative organisms and invitro antioxidant activity by 1,1-diphenyl-2,2-picryl hydrazyl free radical (DPPH) method.