Original Articles: 2015 Vol: 7 Issue: 5
Microwave assisted synthesis of Isoflavones
Abstract
Isoflavones are phenolic natural products occur in nature in plants, they are secondary metabolites. They are molecules of flavonoid family. Isoflavones are derived from 3-phenylchromen-4-one. They possess diversified biological activities. Therefore, various organic/medicinal chemists around the world have developed various synthetic routes methodologies to achieve the target molecules. We wish to report here with a green approach. In our methodology Deoxy benzoin was obtained by treating a substituted phenol with phenyl acetic acid in presence of BF3etherate as a Lewis acid. This intermediate in presence of Vilsmeir reagent and DMF was cyclized under microwave to furnish the product in good yield.