Itopride hydrochloride is a benzamide derivative in the class of prokinetic drugs . it has been approved for the symptomatic treatment of disorders like non-ulcer dyspepsia. chronic gastritis , diadetic gastro paresis or functional dyspepsia. the present study was designed to study the method of development in pharmaceutical dosage forms by reversed hplc . through developed validation method we can analyse the drug in reversed phase pharmaceutical dosage form by hplc. validation is a constant evolving process that starts before an instrument is placed on line and continuous long after method development and transferred. here a new hplc method for itopride hydrochloride and rabeprazole sodium was developed and validated the same. the best chromatographic seperation was performed on phenomenex c18 column and the uv detection wave length was set at 268nm . the mobile phase used was methanol : water : acetonitrile (50:40:10) . the retention time of itopride hydrochloride and rabeprazole sodium was found to be 2100 and 6700 . The final results of retention time was compared with the marketed product.