A simple, sensitive, precise and specific reverse phase high performance liquid chromatographic method was developed and validated for the determination of Asenapine in bulk and tablet dosage forms. It was found that the excipient in the tablet dosage forms does not interfere in the quantification of active drug by proposed method. The HPLC separation was carried out by reverse phase chromatography on Shimadzu HPLC, 10-At detector with hypersil ODS C18 Column 250 X 4.6 mm (particle size of 5μ) and constant flow pump. Rheodyne injector with 20μl loop with a mobile phase composed pure methanol at flow rate 1.0 ml/min. The detection was monitored at 270nm. The calibration curve for Tamsulosin was linear from 2-10mg/ml. The interday and intraday precision was found to be within limits. The proposed method has adequate sensitivity, reproducibility and specificity for the determination of Asenapine in bulk and its tablet dosage forms. LOD and LOQ for Asenapine were found to be 0.4329 and 0.1311.Accuracy (recoveries: 98.07-101.28%) and reproducibility were found to satisfactory.