Basically, patients with diabetes mellitus (DM) is not curable, but they can still a life if controlled. Diabetes can be controlled through management that includes education, food, exercise and medication therapy. Diabetes mellitus is a disease associated with lifestyle. Therefore, success depends on the management of diabetes mellitus patients themselves in changing behavior. One of the changes in behavior is very significant in controlling diabetes is the choice of foods that have a glycemic index or glycemic activity (GI) is low. Reviews these are foods, glucose of able to control blood levels because of decay takes place slowly, and the fluctuation is not high. Rice as the main staple of the Indonesian population has a major role in controlling diabetes, as glycemic activity is varied from low to high. Therefore, glicogenic activity information from a source of staple food consumption is needed. Until the present time, the glycemic index or glycemic activity of various genotypes of rice paddy rice in West Sumatra is still limited.The study was conducted in a laboratory, using experimental animals (mice). Treatments are six types of rice paddy rice genotypes with four replications. The results Showed that Among the six genotypes of the dominant local paddy rice grows in West Sumatra has a glycemic index ranges from moderate to high. Three genotypes were classified as moderate glycemic index is Randah Putiah (63) and Mundam (65). In contrast, Cantiak Manih (66), Ciredek (76), Bakwan (77) and Anak Daro (71) has a glycemic index are relatively high.