Analysis of lipid profile and hormone status betwe en pre menopause and post menopause women was inves tigated. Subject that investigated in this study amounted to 120 people and classified by group of age namely g roup I (30-39 years old), group II (40-49 years old), group III ( 50-59 years old) and group IV ( ≥ 60 years old). The concentration of lipid profile in each age group which includes c holesterol, triglycerides were determined by colori metric enzymatic method. Apolipoprotein determined by spec trophotometry method. Estradiol and FSH level were determined by RIA method. There are significant dif ferences in estradiols level and FSH levels in grou ps II and III (P < 0,001).there was no significant differences in lipid profiles in the age group, except for HDL in group III and IV as well as triglycerides in group II and III. Th ere are significant differences for apolipoprotein B in group I and II, also in group III and IV. the reducing of oestr ogen production from ovaries results change in lipi d profile, leads by reducing HDL and elevating total cholesterol, tr iglyceride, and LDL cholesterol, thus increasing th e risk of cardiovascular disease and breast cancer. The measu rement of Apo-B may have great values in particular some individuals at risk of developing coronary artery d isease are found to have increased level of Apo-B b ut have the normal concentration of cholesterol