The kinetics of oxidation of etamsylate (ETM) by N-chlorobenzenesulphonamide (CAB) in NaOH medium has been investigated at 303K. The reaction rate shows a first order dependence on [CAB]0 and fractional order with respect to both [ETM]0 and [OH-]0 . Effects of added benzenesulphonamide and halide ions have been investigated. The effect of dielectric constant of the medium by varying [MeOH] shows an inverse effect. The variation of ionic strength of the medium has no significant effect on the rate of the reaction. The reaction fails to initiate polymerization of acrylamide. The Michaelis – Menten type of kinetics has been proposed. The reaction was studied at different temperatures and the values of thermodynamic parameters were computed. The reaction stoichiometry and oxidation products have been identified and a suitable mechanism has been proposed.