In acid- base titrations, indicators are used to show a sharp color changes at interval of pH. Natural pigments in plants are highly colored substances and may show color changes with variation of pH. An attempt has been made to investigate the indicator activity of methanolic fruit extract of Punica granatum and to replace the synthetic indicators as they have certain disadvantages like chemical pollution, availability problems and high cost. Methanolic fruit extract of Punica granatum from family Puniceaceae gives sharp and intense color changes as compared to Phenolphthalein, Methyl Red and Phenol Red. Herbal indicators are evaluated by using strong acid-strong base, strong acid-weak base, weak acid-strong base and weak acidweak base. In all these titrations the extract was found to be very useful and accurate for indicating the neutralization point