Isolation of Lactic Acid Bacteria (LAB) were taken from dadih lareh Sago Halaban, have been identified in MRS solid agar medium. The total colony found was 80x108cfu/mL. Six colonies were picked as isolates (S1, S2, S3, S4, S5, S6), concerning their good growth and were identified as lactic acid bacteria based on the morphology, gram stained, and catalase test. Antimicrobial activity screening of LAB isolates were used disc-diffusion method against pathogen bacterias such as Staphylococcus aureus, Salmonella thypii and Escherichia coli in low pH .The six isolate have antimicrobial activity againts pathogen bacteria with varieties of clear zone, and one of them showed the potential as good probiotic and has ability to remove heavy metal of cadmium ions in the solution. The potential one isolate named S5.