A High Performance Liquid Chromatography (HPLC) method was developed for the determination of degradation products of an anti psychotic drug Levosulpiride. The chromatographic separation was achieved on Shimadzu LC- 2010 with PDA system and Hypersil BDS C18 (250x4.6 mm) column using isocratic elution of mobile phase. The present study is aimed to degrade the drug using different forced degradation conditions (as per ICH guidelines) like acid, base, oxidative, thermal and light. One major degradation product was observed in the base and oxidative degradations while no degradation products were observed in acid, thermal and photolytic degradations respectively. The major degraded products were isolated using semi-preparative HPLC. The degraded products were subjected to LC-MS to find out the products mass. The structures of the degradative products were characterized using IR and NMR techniques.