Compound 5, 3'- dihydroxy-7, 4 ', 5'- trimethoxyiso flavon or Vavain has been isolated from ethyl aceta te fraction of kapok ( Ceiba pentandra L.) stem bark was conducted using column chromatography method. Structure eluc idation performed using spectroscopy method (UV-Vis, IR, 1D and 2D NMR). This compound has potential as an antioxidant with IC 50 value is 81.66 μ g/mL and vitamin C as a standard of comparison using rad ical scavenging method.