This in vitro study aims to investigate the antioxidative property and the potential of raw and boiled aqueous extracts of Moringa oleifera (MO) against lead acetate (LA) induced toxicity in goat liver homogenate and LDL (low density lipoprotein) oxidation in human blood plasma. Thereby to prove its efficiency as a hepatoprotectant and antiatherosclerotic agent. The effect on biochemical indices such as lipid peroxidation (LPO), protein level (PL), and enzymatic activities (EA) of vital liver enzymes (alkaline phosphatase, acid phosphatase and succinate dehydrogenase) was examined. Results showed a significant decline in the PL and the EA and increased LPO in LA exposed groups compared to the unexposed control groups. CO administration of the raw and boiled extracts separately to the liver homogenate along with LA increased the PL and EA. It also significantly reduced the formation of TBARS due to LPO caused by LA exposure. Thus, the aqueous extracts of MO might be hepatoprotective. Also the LDL oxidation in human blood plasma induced by LA exposure was reduced in the presence of raw and boiled extracts separately. Thereby confirming that the aqueous extracts of the plant can prevent the formation of atherosclerotic plaques, which is the major risk in cardiovascular diseases. The investigation proves that both raw and boiled aqueous extracts of MO due the presence of potent antioxidants, exerted an ameliorative effect and maintained the studied parameters close to the control groups. This confers its protective role against LA induced hepatotoxicity and prevents the formation of atherosclerotic plaque.