Crossandra infundibuliformis is a popular tropical flower known as “Firecracker”, It is a species of flowering plant in the family Acanthaceae, native to southern India and Sri Lanka. It is traditionally used for the treatment against various ailments in tropical and subtropical parts of India without any scientific knowledge. In the present study the anticancer and insecticidal activity of the ethanolic extract of the leaves of Crossandra infundibuliformis were investigated. Anticancer activity evaluated against human breast cancer cell line (MCF-7) by MTT assay method and the insecticidal activity was evaluated against Wheat weevil (Sitophilus oryzae). Both the activities were dose dependent. IC50 value of anticancer activity against MCF-7 cell line was found to be 404.66 μg/ml. Maximum insecticidal activity (100%) was attained at the concentration of 0.16% and 0.2% ethanolic extract of Crossandra infundibuliformis. Our results confirm that the ethanolic extract of Crossandra infundibuliformis exhibited significant effect against MCF-7 cell lines and Wheat weevil. Anticancer and Insecticidal activity lead some support to the use of Crossandra infundibuliformis for various ailments in the traditional medicine of India.