Study of interactions of bovine serum albumins (BSA) with different metallic nanoparticles (NPs) receives great attention in the recent years due to their key impact in the biomedical field. Interaction can be studied using several methods but due to its high sensitivity and simplicity fluorescence spectroscopy is the most useful one. Detailed characteristics about the interactions of NPs with serum albumin can be derived from the information accumulated by the fluorescence quenching studies. The present review underlies on the interaction of various metallic NPs with BSA. This review helps in understanding the features of NPs essential for their affinity for BSA.