The aim of the study was to evaluate the effectiveness of interventions to promote adherence to antiretroviral therapy of people living with HIV/AIDS. We conducted a systematic review of the literature in the databases LILACS, SciELO, MEDLINE, CINAHL, Scopus and Cochrane, between May and July 2016. We used the keywords "Medication Adherence" and "Antiretroviral Therapy, Highly Active" combined with the Boolean operator AND. It wasfound1589 articles and 26 were selected to analysis. Interventions found include: short message service, telephone call, individual and collective monitoring, directly observed therapy and single tablet regimen. Also, it was found that, in general, the reported results showed that interventions were effective in promoting the adherenceto antiretroviral therapy of people living with HIV/AIDS. It is concluded that the use of targeted interventions for PLWHA in order to increase adherence to ART are effective strategies that improve the health status of patients.