The objective of this study was to investigate the effect of moisture sorption on iron tablet brand and the morphological change, if any, resulting from moisture sorption. Four iron tablets of commercial brands, provided by different sources to Libyan market were examined. Accelerated stability testing was obtained at 40 OC and 75% relative humidity. Changes in physicochemical properties of tablet were determined by weight variation test, hardness test, friability test, disintegration time test, dissolution rate test, thickness & diameter determination and chemical assay by UV- visible Spectrophotometer. The ranking of the storage effect on dissolution test of brand B (slow-fe) was, three months > two month> fresh, while brand A (Tardyferon) two month> fresh > three months, and brand D (Fumafer) fresh > three months > two months, and brand C (Fumacure) three months > two months > fresh. Thus Fumacure had lower tensile strength and disintegration time value than Fumafer and Slow-fe, but Slowfe showed better ability to protect abrasion (friability), brand. Fumacure brand could be useful as an alternative iron tablet brand to three brands especially when used in Libyan markets and the problem of storage and effect of environment condition temperature and relative humidity are of particular concern. The iron content results show that all fresh type samples were within the limit according to Birth pharmacopeia. The ranking of storage effect on the content of iron tablets after the chemical assay by UV-Vis spectrophotometer is for all brands the same, fresh > two months > three months, which indicates that the four brands are affected by the unsuitable storage conditions and being expired, so, furthermore, it will never given the desired treatment