Serum amyloid A have been identified as a potentially useful as a non-invasive biomarker for prognosis of tumors such as breast cancer.The present study aims to evaluate the associations between SAA and hormones in breast tumor, and the possibility use gel electrophoresis as a tool for SAA diagnosis. A total of 77 patient attending center of Breast Cancer, and33 healthy individual as a control were included in this study. The results indicated a significant increase of BMI,SAA,CRP, globulin and a significant decrease in albumin level in sera of benign and malignant groups compared with control group.A significant decrease in E2 level was observed in postmenopausal malignant compared with control.Three bands were observed in gel electrophoresis. Our conclusion that SAA may be useful as a tumor marker and it can be possible to adopt gel electrophoresis as laboratory technique for detection presence of SAA.

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