This paper aims to reduce nursing risk in the process of hemodialysis which provides hemodialysis patients with secure superior nursing service. Methods are based on the knowledge of risk management guidance, by identifying the dialysis process existing and potential nursing risks, to guide the clinical care and reduce the risk and ensure the safety of nursing care. Results of this paper are reduction of the nursing defect and Improving the dialysis patient satisfaction with nursing work. In conclusion, in the risk management of hemodialysis, strengthening nurses' risk awareness and ability and enhancing the sense of responsibility are the keys of risk management. Improving the service quality is the basic guarantee.